[Editors' Choice] A new therapeutic target for myelofibrosis is cause for Gli

Source: http://stm.sciencemag.org/cgi/content/short/9/392/eaan4297?rss=1
May 31, 2017 at 08:51PM

Myeloproliferative neoplasm cells recruit Gli1 positive mesenchymal stromal cells to transdifferentiate into fibrosis-causing myofibroblasts, a process that can be inhibited by a Gli inhibitor.